Macedonian Prva Liga 2021/2022: final table of First division
| # | Club | M | W | D | L | Goal | Pts | GD | Result | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Shkupi | 33 | 23 | 7 | 3 | 66 - 21 | 76 | +45 |   Champion (Champions League) | |
| 2 | Akademija Pandev | 33 | 19 | 7 | 7 | 55 - 32 | 64 | +23 | Europa Conference League | |
| 3 | Shkendija 79 | 33 | 16 | 13 | 4 | 49 - 25 | 61 | +24 | Europa Conference League | |
| 4 | Makedonija Gjorce Petrov | 33 | 17 | 6 | 10 | 46 - 44 | 57 | +2 | Europa Conference League | |
| 5 | Renova | 33 | 12 | 12 | 9 | 42 - 29 | 48 | +13 | ||
| 6 | Struga Trim-Lum | 33 | 12 | 11 | 10 | 33 - 33 | 47 | ±0 | ||
| 7 | Bregalnica Stip | 33 | 12 | 9 | 12 | 45 - 47 | 45 | -2 | ||
| 8 | Rabotnicki | 33 | 13 | 4 | 16 | 29 - 35 | 43 | -6 | ||
| 9 | Skopje | 33 | 9 | 8 | 16 | 27 - 45 | 35 | -18 | Relegation Playoff | |
| 10 | Tikves | 33 | 9 | 7 | 17 | 36 - 38 | 34 | -2 | Relegation Playoff | |
| 11 | Borec | 33 | 5 | 6 | 22 | 25 - 66 | 21 | -41 |  Relegated | |
| 12 | Pelister | 33 | 2 | 8 | 23 | 16 - 54 | 14 | -38 | Relegated | |
| Pts = Points M = Matches played; W = Matches won; D = Matches drawn; L = Matches lost; GD = Goal difference; | ||||||||||
Notes:
- Champion
 - national cup holder
- participation in European competition
 - promoted
- relegated
|
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2020/2021
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